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Researchers take an early step toward developing a new class of therapeutics for patients with a deadly blood cancer

The team has discovered that for acute myeloid leukemia (AML) patients, there is a dopamine receptor pathway that becomes abnormally activated in the cancer stem cells. This inspired the clinical investigation of a dopamine receptor-inhibiting drug thioridazine as a new therapy for patients, and their focus on adult AML has revealed encouraging results.

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Multiple blood feeding in mosquitoes increases malaria transmission potential

Multiple bouts of blood feeding by mosquitoes shorten the incubation period for malaria parasites and increase malaria transmission potential, according to a study published in the open-access journal PLOS Pathogens by Lauren Childs of Virginia Tech, Flaminia Catteruccia of the Harvard T.H. Chan School of Public Health, and colleagues.

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