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Inferring a network from dynamical signals at its nodes

by Corey Weistuch, Luca Agozzino, Lilianne R. Mujica-Parodi, Ken A. Dill

We give an approximate solution to the difficult inverse problem of inferring the topology of an unknown network from given time-dependent signals at the nodes. For example, we measure signals from individual neurons in the brain, and infer how they are inter-connected. We use Maximum Caliber as an inference principle. The combinatorial challenge of high-dimensional data is handled using two different approximations to the pairwise couplings. We show two proofs of principle: in a nonlinear genetic toggle switch circuit, and in a toy neural network.


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Paper source
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008435

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