Estimation of neuron parameters from imperfect observations

by Joseph D. Taylor, Samuel Winnall, Alain Nogaret

The estimation of parameters controlling the electrical properties of biological neurons is essential to determine their complement of ion channels and to understand the function of biological circuits. By synchronizing conductance models to time series observations of the membrane voltage, one may construct models capable of predicting neuronal dynamics. However, identifying the actual set of parameters of biological ion channels remains a formidable theoretical challenge. Here, we present a regularization method that improves convergence towards this optimal solution when data are noisy and the model is unknown. Our method relies on the existence of an offset in parameter space arising from the interplay between model nonlinearity and experimental error. By tuning this offset, we induce saddle-node bifurcations from sub-optimal to optimal solutions. This regularization method increases the probability of finding the optimal set of parameters from 67% to 94.3%. We also reduce parameter correlations by implementing adaptive sampling and stimulation protocols compatible with parameter identifiability requirements. Our results show that the optimal model parameters may be inferred from imperfect observations provided the conditions of observability and identifiability are fulfilled.

Make more money selling and advertising your products and services for free on Ominy market. Click here to start selling now

Paper source
Plos Journal

READ MORE  Insights into malaria pathogenesis gained from host metabolomics

Ominy science editory team

A team of dedicated users that search, fetch and publish research stories for Ominy science.

Enable notifications of new posts    OK No thanks