The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian circadian gene expressionRead more
Many proteins contain multiple folded domains separated by flexible linkers, and the ability to describe the structure and conformational heterogeneity of such flexible systems pushes the limits of structural biology.Read more
The sudden shift in the way Americans shop is stunning we used a marble machine to unpack what’s going wrong.Read more
An elevated level of serum uric acid (SUA) is associated with an increased risk of cardiovascular disease. Pharmacological intervention with urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, allopurinol, has been used widely for a long period of time in clinical practice to reduce SUA levels.Read more
Researchers at the Wyss Institute at Harvard University, in collaboration with health care, research, and industrial partners, have designed a new, fully injection-molded nasopharyngeal swab that can be manufactured quickly and inexpensively at high volume to help address the nationwide and international shortage of swabs for COVID-19 testing and research.Read more
The mechanisms underlying virus emergence are rarely well understood, making the appearance of outbreaks largely unpredictable. Bluetongue virus serotype 8 (BTV-8), an arthropod-borne virus of ruminants, emerged in livestock in northern Europe in 2006, spreading to most European countries by 2009 and causing losses of billions of euros.Read more
As cities around the world close off select streets to through traffic during the pandemic, New York has lagged behind. Even though this is the densest city in the country and the area currently hardest hit by coronavirus in the world, Mayor Bill de Blasio has dragged his feet on giving New Yorkers breathing room by designating some streets car-free.Read more
In 2015, there were approximately 40,000 new HIV diagnoses in the United States. Pre-exposure prophylaxis (PrEP) is an effective strategy that reduces the risk of HIV acquisition; however, uptake among those who can benefit from it has lagged.Read more
The American Conservation Coalition (ACC) might be the only environmental group on the planet that thinks the United States shouldn’t rejoin the Paris climate agreement.Read more
Both intimate partner violence (IPV) and alcohol misuse are highly prevalent, and partner alcohol misuse is a significant contributor to women’s risk for IPV.
There are few evidence-based interventions to address these problems in low- and middle-income countries (LMICs).