How does your brain sense an itch(pruritus)

Light touch plays a critical role in everyday tasks, such as picking up a glass or playing a musical instrument. The sensation is also an essential part of the body’s protective defense system, alerting us to objects in our environment that could cause us to fall or injure ourselves.

In addition, it is part of the detection system that has evolved to protect us from biting insects, such as those that cause malaria and Lyme disease, by eliciting a feeling of an itch when an insect lands on your skin.

Before we go go into the full research, lets answer some common questions about itch

What is an itch and why do we itch??

An itch also known as pruritus is a general uncomfortable sensation that arises from the irritation of skin cells which creates an urge to scratch the skin.

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This itching sensations sensations can occur on any part of the body, although Itching ( pruritus ) can be a source of nuisance, it serves as a defense mechanism to the body. Pruritus is a very common symptom of most skin diseases.

How does itching work

Itching involves the activation of the pruriceptors of specialized nerve cells called C-fibers. These C-fibers are similar to those associated with the sensation of pain, but they are functionally distinct and only convey the itch sensation. They comprise about 5 percent of the total C-fibers in human skin.

When stimulated superficially on the skin, these C-fibers carry signals along the nerve to the spinal cord and on to the brain, where they are processed, generating a scratching or rubbing reflex response. Scratching and rubbing then interfere with the sensations arising from pruriceptors by stimulating various pain and touch receptors in the same areas.

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What happens if you don’t scratch an itch

Itching is the bodies defense mechanism. If you don’t scratch an itch, the sensations will keep getting intense till the pruriceptors of specialized nerve cells called C-fibers is deactivated.

Why does my skin feel more itchy when i scratch

When you scratch an itchy skin it causes the brain to release a hormone called serotonin which intensifies your itch

Why do you feel relieved when you scratch an itch

When you scratch an itch, the low-level pain signal increases in your brain, overriding the itchy signal

Does scratching an itch release dopamin

Scratching an itch does not cause the release of dopamin

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Now, Salk researchers have discovered how neurons in the spinal cord help transmit such itch signals to the brain. Published in the journal Cell Reports, their findings help contribute to a better understanding of itch and could lead to new drugs to treat chronic itch, which occurs in such conditions as eczema, diabetes and even some cancers.

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“The takeaway is that this mechanical itch sensation is distinct from other forms of touch and it has this specialized pathway within the spinal cord,”

says Salk Professor Martyn Goulding, holder of the Frederick W. and Joanna J. Mitchell Chair and a senior author of the new work.

Goulding and his colleagues had previously discovered a set of inhibitory neurons in the spinal cord that act like cellular brakes, keeping the mechanical itch pathway in the spinal cord turned off most of the time.

Without these neurons, which produce the neurotransmitter neuropeptide Y (NPY), the mechanical itch pathway is constantly on, causing chronic itch. What the researchers didn’t know was how the itch signal, which under normal circumstances is suppressed by the NPY neurons, is transmitted to the brain to register the itch sensation.

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David Acton, a postdoctoral fellow in the Goulding lab, hypothesized that when the NPY inhibitory neurons are missing, neurons in the spinal cord that normally transmit light touch begin to act like an accelerator stuck in the “on” position. Acton then identified a candidate for these “light touch neurons,” a population of excitatory neurons in the spinal cord that express the receptor for NPY, the so-called Y1 spinal neurons.

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To test whether these neurons were indeed acting like an accelerator, Acton undertook an experiment that involved selectively getting rid of both the NPY “brake” and Y1 “accelerator” neurons. Without Y1 neurons, mice didn’t scratch, even in response to light-touch stimuli that normally make them scratch.

Moreover, when Acton gave the animals drugs that activated the Y1 neurons, the mice scratched spontaneously even in the absence of any touch stimuli. The Goulding team was then able to show that the NPY neurotransmitter controls the level of Y1 neuron excitability; in other words, NPY signaling acts as a kind of thermostat to control our sensitivity to light touch.

Data from other labs has found that some people with psoriasis have lower than average levels of NPY. This may mean their brakes on mechanical itching are less effective than other people’s, a potential cause of their itching.

While Y1 neurons transmit the itch signal in the spinal cord, other neurons are thought to be responsible for mediating the final response in the brain but more research is needed to continue mapping out the full pathway, according to the researchers. Understanding this will help suggest targets for drugs to turn down the sensation of itch in people who are overly responsive and could lead to ways to address chronic itch.

“By working out mechanisms by which mechanical itch is signaled under normal circumstances, we might then be able to address what happens in chronic itch,”

says Acton.

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Story source

Salk Institute

The above research story was published on

Cell reports

Ibezim chukwuemerie

EDM freak... Digital marketer... Tech savvy... In love with human science... Studies zoology at University of Nigeria... Chief editor at Ominy science. Follow him on Twitter and Instagram or like our page on Facebook

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